1. Full-spectrum hyperacute immune‑induced NDV platform
Based on the NDV platform, three functionalized viral backbones (GGTA1, CMAH, and B4GALNT2) have been established, forming a development foundation covering multiple hyperacute immune mechanisms (related technology has been granted invention patents).
2. Functionally complete NDV‑GT
NDV‑GT uses the full functional sequence of GGTA1 as a construction template, helping to enhance the expression of functions related to hyperacute immune rejection (related patent applications have been filed).
3. NDV‑Gene1‑Gene2‑Gene3
The platform vector supports the simultaneous insertion of up to three exogenous expression units, suitable for multi‑gene functional combination designs.
4. Customized NDV modifications
Custom modifications are available, including tropism optimization, enhanced expression functions, and defective‑type safety optimization.
5. High‑titer stable production
High‑titer stable production is achieved, with viral titers reaching above 10⁸ PFU/mL.
Recombinant Newcastle disease virus oncolytic virus customization platform
NDViraFLEX is a customized technology platform developed by MeltonVEC™ based on recombinant Newcastle disease virus, which can be used for oncolytic virus backbone construction, exogenous gene insertion, functional module design, and candidate virus development.
The platform focuses on meeting diverse needs in scientific research and translational research, providing customized support for solid tumor‑related studies, viral functional evaluation, and the development of innovative oncolytic viruses.
NDV Engineering & Packaging Service
Service process
① Requirement communication: Confirm the exogenous gene sequence, expression requirements, and project goals.
② Vector design: Optimize the insertion site and expression strategy according to project needs.
③ Virus rescue: Complete recombinant virus packaging and rescue using a helper cell system.
④ Virus amplification and purification: Amplification can be performed using embryonated eggs or cell culture systems, followed by purification as required.
⑤ Quality control: Provide authentic active titer detection (PFU/mL), exogenous gene expression validation, sterility testing, and mycoplasma‑free testing.
| Technical capabilities | |
| Exogenous gene insertion | Supports insertion of up to 2 exogenous genes into the NDV-LaSota strain genome, enabling separate expression of two independent CDSs. |
| Types of genes for insertion | Supports various functional elements such as therapy-related genes, immune modulators, reporter genes (e.g., fluorescent proteins), and targeting peptides. |
| Virus construction capability | Utilizes reverse genetics technology for recombinant NDV construction, balancing gene insertion accuracy with viral viability. |
Deliverables
Recombinant NDV virus samples: viral allantoic fluid or purified virus solution
Project experimental report: including construction strategy and QC data
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